Conformational changes and protein stability of the pro-apoptotic protein Bax
نویسندگان
چکیده
منابع مشابه
Conformational changes and protein stability of the pro-apoptotic protein Bax
Pro-apoptotic Bax is a soluble and monomeric protein under normal physiological conditions. Upon its activation substantial structural rearrangements occur: The protein inserts into the mitochondrial outer membrane and forms higher molecular weight oligomers. Subsequently, the cells can undergo apoptosis. In our studies, we focused on the structural rearrangements of Bax during oligomerization ...
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Expression of the Pro-apoptotic Protein Bax is Reduced in Bronchial Mucous Cells of Asthmatics
The present studies were designed to determine whether our findings in mice showing that the Bcl-2-associated protein X (Bax) plays a role in the resolution of allergen-induced mucous cell metaplasia can be applied to asthma in humans. Immunostaining of autopsy tissues from mild and severe asthmatics showed a significant reduction in the percentage of Bax-positive mucous cells compared to those...
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ژورنال
عنوان ژورنال: Journal of Bioenergetics and Biomembranes
سال: 2009
ISSN: 0145-479X,1573-6881
DOI: 10.1007/s10863-009-9202-1